Ispra can be reached in various ways; by car, by bus and, limited to the summer period, by the navigation service on the waters of Lake Maggiore.

Coming from Milan, it is possible to take the A8 motorway towards Varese. When you reach Gallarate, turn left towards Gravellona Toce and exit at Vergiate-Sesto Calende. Leaving the motorway, take the SS n.33 towards Sesto Calende and once in the center of Sesto Calende, turn left onto the SS n. 629 towards Laveno Mombello.
Or, at the Vergiate-Sesto Calende exit, take the SS 629 and continue to Comabbio. Then turn left towards Cadrezzate con Osmate from where you reach Ispra.
Coming from Varese take the SS n. 394 in the direction of Laveno Mombello and, once in Gavirate, take the direction of Ispra-Angera. Or from Varese it is possible to take the SP1 always in the direction of Laveno Mombello and in Gavirate take the SP50.

Ispra is connected by the TPL VARESE-ANGERA-SESTO C. – line managed by the company Autolinee Varesine (+39.0332.731110).

The lake connection service is managed by Navigazione Lago Maggiore company. The Ispra airport is active only in the summer period.

The stations closest to Ispra on the Trenitalia – Trenord lines are: Besozzo (Milan Luino), Sesto Calende (Milan-Domodossola line), Gavirate (Milan Cadorna – Laveno Mombello FNM). To reach Ispra it is then necessary to use other means of transport (bus)